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Vaccines inducing immunity to Lassa virus glycoprotein and nucleoprotein protect macaques after a single shot

2 Oct 2019

Abstract excerpt

Lassa fever is a major threat in Western Africa. The large number of people living at risk for this disease calls for the development of a vaccine against Lassa virus (LASV). We generated live-attenuated LASV vaccines based on measles virus and Mopeia virus platforms and expressing different LASV antigens, with the aim to develop a vaccine able to protect after a single shot. We compared the efficacy of these...

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PMID: 31578242
DOI: 10.1126/scitranslmed.aaw3163

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