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Article

Development of Live-Attenuated Arenavirus Vaccines Based on Codon Deoptimization

15 Jan 2015

Abstract excerpt

UNLABELLED: Arenaviruses have a significant impact on public health and pose a credible biodefense threat, but the development of safe and effective arenavirus vaccines has remained elusive, and currently, no Food and Drug Administration (FDA)-licensed arenavirus vaccines are available. Here, we explored the use of a codon deoptimization (CD)-based approach as a novel strategy to develop live-attenuated...

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Identifiers

PMID: 25589652
DOI: 10.1128/jvi.03401-14

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