Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Remarkable effect of transdermal nicotine in children with CHRNA4-related autosomal dominant sleep-related hypermotor epilepsy.

Epilepsy & behavior : E&B - 1 Apr 2020

Lossius Kristine, de Saint Martin Anne, Myren-Svelstad Sverre, Bjørnvold Marit, Minken Guro, Seegmuller Caroline, Valenti Hirsch Maria Paola, Chelly Jamel, Steinlein Ortrud, Picard Fabienne, Brodtkorb Eylert

Abstract excerpt

OBJECTIVE: Autosomal dominant sleep-related hypermotor epilepsy (ADSHE) is characterized by hypermotor seizures and may be caused by gain-of-function mutations affecting the nicotinic acetylcholine receptor (nAChR). Benefit from nicotine consumption has been reported in adult patients with this disorder. For the first time, the effect of transdermal nicotine is evaluated in children. METHODS: Transdermal nicotine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Child

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epilepsy, Reflex

Share to Mutation

Share to Nicotine

Share to Receptors, Nicotinic

Share to Treatment Outcome

Source

Identifiers

PMID: 32097883
DOI: 10.1016/j.yebeh.2020.106944

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Remarkable effect of transdermal nicotine in children with CHRNA4-related autosomal dominant sleep-related hypermotor epilepsy.PMID 32097883Read ↗

Nicotine: A Targeted Therapy for Epilepsy Due to nAChR Gene Variants.Semantic proximity Read ↗

Nicotine as target-therapy in Sleep-Related Hypermotor Epilepsy due to nAChR genes mutation: case report and systematic review of literature.Semantic proximity Read ↗

Nicotinic acetylcholine receptors and epilepsy.Semantic proximity Read ↗

Pathogenesis and pathophysiology of autosomal dominant sleep‐related hypermotor epilepsy with S284L‐mutant α4 subunit of nicotinic ACh receptorSemantic proximity Read ↗

Nicotinic acetylcholine receptors and epilepsy.Semantic proximity Read ↗

The role of the nicotinic acetylcholine receptors in sleep-related epilepsy.Semantic proximity Read ↗

Rats harboring S284L Chrna4 mutation show attenuation of synaptic and extrasynaptic GABAergic transmission and exhibit the nocturnal frontal lobe epilepsy phenotype.Semantic proximity Read ↗

Neuronal nicotinic acetylcholine receptors: their properties and alterations in autosomal dominant nocturnal frontal lobe epilepsy.Semantic proximity Read ↗

Pleiotropic functional effects of the first epilepsy-associated mutation in the human CHRNA2 gene.Semantic proximity Read ↗

Mutations of the neuronal nicotinic acetylcholine receptors and their association with ADNFLE.Semantic proximity Read ↗

The neuronal nicotinic acetylcholine receptor in some hereditary epilepsies.Semantic proximity Read ↗

Nicotine-induced dystonic arousal complex in a mouse line harboring a human autosomal-dominant nocturnal frontal lobe epilepsy mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.