Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pathogenesis and pathophysiology of autosomal dominant sleep‐related hypermotor epilepsy with S284L‐mutant α4 subunit of nicotinic ACh receptor

4 Jan 2020

Abstract excerpt

BACKGROUND AND PURPOSE: The mechanisms causing spontaneous epileptic seizures, including carbamazepine-resistant/zonisamide -sensitive seizures and comorbidity in autosomal dominant sleep-related hypermotor epilepsy (ADSHE) are unclear. This study investigated functional abnormalities in thalamocortical transmission in transgenic rats bearing rat S286L-mutant Chrna4 (S286L-TG) of α4 subunit of the nicotinic ACh...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epilepsy research and treatment
Share to Nicotinic Acetylcholine Receptors Study
Share to Sleep and Wakefulness Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31901135
DOI: 10.1111/bph.14974

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pathogenesis and pathophysiology of autosomal dominant sleep‐related hypermotor epilepsy with S284L‐mutant α4 subunit of nicotinic ACh receptorPMID 31901135Read ↗

Pathomechanism of nocturnal paroxysmal dystonia in autosomal dominant sleep-related hypermotor epilepsy with S284L-mutant α4 subunit of nicotinic ACh receptor.Semantic proximity Read ↗

Nicotinic acetylcholine receptors and epilepsy.Semantic proximity Read ↗

Can rodent models elucidate the pathomechanisms of genetic epilepsy?Semantic proximity Read ↗

Nicotine as target-therapy in Sleep-Related Hypermotor Epilepsy due to nAChR genes mutation: case report and systematic review of literature.Semantic proximity Read ↗

Nicotine: A Targeted Therapy for Epilepsy Due to nAChR Gene Variants.Semantic proximity Read ↗

Mutations of the neuronal nicotinic acetylcholine receptors and their association with ADNFLE.Semantic proximity Read ↗

Nicotinic receptor channelopathies and epilepsy.Semantic proximity Read ↗

The role of the nicotinic acetylcholine receptors in sleep-related epilepsy.Semantic proximity Read ↗

Human disorders caused by the disruption of the regulation of excitatory neurotransmission.Semantic proximity Read ↗

Neuronal nicotinic acetylcholine receptors: from the gene to the disease.Semantic proximity Read ↗

Revisiting the role of neurotransmitters in epilepsy: An updated review.Semantic proximity Read ↗

Rats harboring S284L Chrna4 mutation show attenuation of synaptic and extrasynaptic GABAergic transmission and exhibit the nocturnal frontal lobe epilepsy phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.