Article
Nicotinic acetylcholine receptors and epilepsy.
Current drug targets. CNS and neurological disorders - 1 Aug 2002
Steinlein Ortrud K
Abstract excerpt
The neuronal nicotinic acetylcholine receptors (nAChRs) have multiple roles in the brain: they are involved in signal transduction by fast synaptic transmission, axo-axonic transmission, and in the modulation of presynaptic transmitter release. Presynaptic nAChRs can increase the release of excitatory as well as of inhibitory transmitters, and can thereby control neuronal excitability. Furthermore, nAChRs which...
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