Rats harboring S284L Chrna4 mutation show attenuation of synaptic and extrasynaptic GABAergic transmission and exhibit the nocturnal frontal lobe epilepsy phenotype.

doi:10.1523/JNEUROSCI.2961-08.2008

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Article

Rats harboring S284L Chrna4 mutation show attenuation of synaptic and extrasynaptic GABAergic transmission and exhibit the nocturnal frontal lobe epilepsy phenotype.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 19 Nov 2008

Zhu Gang, Okada Motohiro, Yoshida Shukuko, Ueno Shinya, Mori Fumiaki, Takahara Tomoko, Saito Ryo, Miura Yoshiki, Kishi Akihiro, Tomiyama Masahiko, Sato Akira, Kojima Toshio, Fukuma Goryu, Wakabayashi Koichi, Hase Koji, Ohno Hiroshi, Kijima Hiroshi, Takano Yukio, Mitsudome Akihisa, Kaneko Sunao, Hirose Shinichi

Abstract excerpt

Mutations of genes encoding alpha4, beta2, or alpha2 subunits (CHRNA4, CHRNB2, or CHRNA2, respectively) of nAChR [neuronal nicotinic ACh (acetylcholine) receptor] cause nocturnal frontal lobe epilepsy (NFLE) in human. NFLE-related seizures are seen exclusively during sleep and are characterized by three distinct seizure phenotypes: "paroxysmal arousals," "paroxysmal dystonia," and "episodic wandering." We...

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Identifiers

PMID: 19020039
DOI: 10.1523/JNEUROSCI.2961-08.2008
PMCID: PMC6671721

Genes

CHRNA4
CHRNA2
CHRNB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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