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Article

Nicotine as target-therapy in Sleep-Related Hypermotor Epilepsy due to nAChR genes mutation: case report and systematic review of literature.

Sleep medicine - 1 Jan 2026

Tiscornia Maddalena, Bosisio Luca, Torta Francesca, Franchina Maria Paola, Chiarella Lorenzo, Marazzotta Valentina, Iadarola Antonella, Nobili Lino, Nobile Giulia

Abstract excerpt

OBJECTIVE: Ten to fifteen per cent of Sleep-Related-Hypermotor-Epilepsy (SHE) has genetic origin, mainly related to pathogenic variants of genes coding for nicotinic cholinergic receptor (nAChR) system. We reported a subject with SHE due to CHRNA4 mutation, successfully treated with Nicotine. We also provided a systematic review on the use of Nicotine as an anti-seizure-medication and sleep regulator in SHE due...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41192108
DOI: 10.1016/j.sleep.2025.106884

Genes

SHE
CHRNA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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