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Article

The SR protein RSP-2 influences expression of the truncated insulin receptor DAF-2B in Caenorhabditis elegans.

G3 (Bethesda, Md.) - 1 Jun 2023

Martinez Bryan A, Gill Matthew S

Abstract excerpt

The alternatively spliced daf-2b transcript in Caenorhabditis elegans encodes a truncated isoform of the nematode insulin receptor that retains the extracellular ligand binding domain but lacks the intracellular signaling domain and is therefore unable to transduce a signal. To identify factors that influence expression of daf-2b, we performed a targeted RNA interference screen of rsp genes, which encode splicing...

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Identifiers

PMID: 36966398
DOI: 10.1093/g3journal/jkad064
PMCID: PMC10234397

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