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Article

Metformin targets gastric cancer stem cells.

European journal of cancer (Oxford, England : 1990) - 1 Oct 2017

Courtois Sarah, Durán Raúl V, Giraud Julie, Sifré Elodie, Izotte Julien, Mégraud Francis, Lehours Philippe, Varon Christine, Bessède Emilie

Abstract excerpt

Gastric cancer is the third leading cause of cancer-related deaths worldwide and has still a poor prognosis. Therefore, new therapeutic strategies are needed: among them, targeting cancer stem cells (CSCs) could offer new opportunities. The aim of our study was to evaluate the anti-tumoural effect of metformin on gastric cancer in vitro and in vivo and especially, to determine whether this molecule could target...

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PMID: 28822889
DOI: 10.1016/j.ejca.2017.07.020

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