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Article

Rapid in vivo evaluation system for cholestasis-related genes in mice with humanized bile acid profiles.

Hepatology communications - 1 Apr 2024

Wakasa Kihiro, Tamura Ryutaro, Osaka Shuhei, Takei Hajime, Asai Akihiro, Nittono Hiroshi, Kusuhara Hiroyuki, Hayashi Hisamitsu

Abstract excerpt

BACKGROUND: Pediatric cholestatic liver diseases (Ped-CLD) comprise many ultrarare disorders with a genetic basis. Pharmacologic therapy for severe cases of Ped-CLD has not been established. Species differences in bile acid (BA) metabolism between humans and rodents contribute to the lack of phenocopy of patients with Ped-CLD in rodents and hinder the development of therapeutic strategies. We aimed to establish...

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Identifiers

PMID: 38517206
DOI: 10.1097/HC9.0000000000000382
PMCID: PMC10962888

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