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Article

Rapid Disruption of Genes Specifically in Livers of Mice Using Multiplex CRISPR/Cas9 Editing.

Gastroenterology - 1 Dec 2018

Pankowicz Francis P, Barzi Mercedes, Kim Kang Ho, Legras Xavier, Martins Celeste Santos, Wooton-Kee Clavia Ruth, Lagor William R, Marini Juan C, Elsea Sarah H, Bissig-Choisat Beatrice, Moore David D, Bissig Karl-Dimiter

Abstract excerpt

BACKGROUND & AIMS: Despite advances in gene editing technologies, generation of tissue-specific knockout mice is time-consuming. We used CRISPR/Cas9-mediated genome editing to disrupt genes in livers of adult mice in just a few months, which we refer to as somatic liver knockouts. METHODS: In this system, Fah-/- mice are given hydrodynamic tail vein injections of plasmids carrying CRISPR/Cas9 designed to excise...

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Share to ATP Binding Cassette Transporter, Subfamily B, Member 11
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Identifiers

PMID: 30170115
DOI: 10.1053/j.gastro.2018.08.037
PMCID: PMC6420307

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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