Article

Impaired cholesterol metabolism in the mice model of cystic fibrosis. A vicious circle?

2019-12-13

Abstract excerpt

Patients with cystic fibrosis (CF) have low cholesterol absorption and, despite enhanced endogenous biosynthesis, low serum cholesterol. Herein, we investigated cholesterol metabolism in a murine CF model in comparison to wild type (WT) testing serum and liver surrogate biomarkers together with the hepatic expression of genes involved in cholesterol metabolism. CF mice display lower sterols absorption and increas...

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Literature Corpus work: e806f6d1-6742-5f4b-96ea-e12326822f29
DOI: 10.1101/2019.12.13.875336

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