Article
MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodeling.
Genes & development - 1 Apr 2020
Venkatesh Divya, O'Brien Nicholas A, Zandkarimi Fereshteh, Tong David R, Stokes Michael E, Dunn Denise E, Kengmana Everett S, Aron Allegra T, Klein Alyssa M, Csuka Joleen M, Moon Sung-Hwan, Conrad Marcus, Chang Christopher J, Lo Donald C, D'Alessandro Angelo, Prives Carol, Stockwell Brent R
Abstract excerpt
MDM2 and MDMX, negative regulators of the tumor suppressor p53, can work separately and as a heteromeric complex to restrain p53's functions. MDM2 also has pro-oncogenic roles in cells, tissues, and animals that are independent of p53. There is less information available about p53-independent roles of MDMX or the MDM2-MDMX complex. We found that MDM2 and MDMX facilitate ferroptosis in cells with or without p53....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.