Article
Electron and Proton Transfers Modulate DNA Binding by the Transcription Regulator RsrR.
Journal of the American Chemical Society - 18 Mar 2020
Crack Jason C, Amara Patricia, Volbeda Anne, Mouesca Jean-Marie, Rohac Roman, Pellicer Martinez Ma Teresa, Huang Chia-Ying, Gigarel Océane, Rinaldi Clara, Le Brun Nick E, Fontecilla-Camps Juan C
Abstract excerpt
The [Fe2S2]-RsrR gene transcription regulator senses the redox status in bacteria by modulating DNA binding, while its cluster cycles between +1 and +2 states-only the latter binds DNA. We have previously shown that RsrR can undergo remarkable conformational changes involving a 100° rotation of tryptophan 9 between exposed (Out) and buried (In) states. Here, we have used the chemical modification of Trp9,...
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