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Article

Revisiting the pH-gated conformational switch on the activities of HisKA-family histidine kinases.

Nature communications - 7 Feb 2020

Mideros-Mora Cristina, Miguel-Romero Laura, Felipe-Ruiz Alonso, Casino Patricia, Marina Alberto

Abstract excerpt

Histidine is a versatile residue playing key roles in enzyme catalysis thanks to the chemistry of its imidazole group that can serve as nucleophile, general acid or base depending on its protonation state. In bacteria, signal transduction relies on two-component systems (TCS) which comprise a sensor histidine kinase (HK) containing a phosphorylatable catalytic His with phosphotransfer and phosphatase activities...

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Identifiers

PMID: 32034139
DOI: 10.1038/s41467-020-14540-5
PMCID: PMC7005713

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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