Article
The role of electrostatics in TrxR electron transfer mechanism: A computational approach.
Proteins - 1 Dec 2016
Teixeira Vitor H, Capacho Ana Sofia C, Machuqueiro Miguel
Abstract excerpt
Thioredoxin reductase (TrxR) is an important enzyme in the control of the intracellular reduced redox environment. It transfers electrons from NADPH to several molecules, including its natural partner, thioredoxin. Although there is a generally accepted model describing how the electrons are transferred along TrxR, which involves a flexible arm working as a "shuttle," the molecular details of such mechanism are...
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