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Article

Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma.

European journal of human genetics : EJHG - 1 Jun 2010

Gao Pei-Song, Shimizu Kenichi, Grant Audrey V, Rafaels Nicholas, Zhou Lin-Fu, Hudson Sherry A, Konno Satoshi, Zimmermann Nives, Araujo Maria I, Ponte Eduardo V, Cruz Alvaro A, Nishimura Masaharu, Su Song-Nan, Hizawa Nobuyuki, Beaty Terry H, Mathias Rasika A, Rothenberg Marc E, Barnes Kathleen C, Bochner Bruce S

Abstract excerpt

Sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) promotes the apoptosis of eosinophils and inhibits FcvarepsilonRI-dependent mediator release from mast cells. We investigated the genetic association between sequence variants in Siglec-8 and diagnosis of asthma, total levels of serum Ig...

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Identifiers

PMID: 20087405
DOI: 10.1038/ejhg.2009.239
PMCID: PMC2987348

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20087405-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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