Article
Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma.
European journal of human genetics : EJHG - 1 Jun 2010
Gao Pei-Song, Shimizu Kenichi, Grant Audrey V, Rafaels Nicholas, Zhou Lin-Fu, Hudson Sherry A, Konno Satoshi, Zimmermann Nives, Araujo Maria I, Ponte Eduardo V, Cruz Alvaro A, Nishimura Masaharu, Su Song-Nan, Hizawa Nobuyuki, Beaty Terry H, Mathias Rasika A, Rothenberg Marc E, Barnes Kathleen C, Bochner Bruce S
Abstract excerpt
Sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) promotes the apoptosis of eosinophils and inhibits FcvarepsilonRI-dependent mediator release from mast cells. We investigated the genetic association between sequence variants in Siglec-8 and diagnosis of asthma, total levels of serum IgE (tIgE), and diagnosis of eosinophilic esophagitis (EE) in diverse populations. The effect of sequence variants on...
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