Article
Nucleotide Excision Repair Protein Rad23 Regulates Cell Virulence Independent of Rad4 in Candida albicans.
mSphere - 19 Feb 2020
Feng Jia, Yao Shuangyan, Dong Yansong, Hu Jing, Whiteway Malcolm, Feng Jinrong
Abstract excerpt
In the pathogenic yeast Candida albicans, the DNA damage response contributes to pathogenicity by regulating cell morphology transitions and maintaining survival in response to DNA damage induced by reactive oxygen species (ROS) in host cells. However, the function of nucleotide excision repair (NER) in C. albicans has not been extensively investigated. To better understand the DNA damage response and its role in...
Topics
- Animals
- Biofilms
- Candida albicans
- DNA Damage
- DNA Repair
- Fungal Proteins
- Gene Deletion
- Gene Expression Regulation, Fungal
- Macrophages
- Male
- Mice
- Mice, Inbred BALB C
- Mutation
- RAW 264.7 Cells
- Ultraviolet Rays
- Virulence
- Virulence Factors