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Article

The moonlighting of RAD23 in DNA repair and protein degradation.

Biochimica et biophysica acta. Gene regulatory mechanisms - 1 Jun 2023

Grønbæk-Thygesen Martin, Kampmeyer Caroline, Hofmann Kay, Hartmann-Petersen Rasmus

Abstract excerpt

A moonlighting protein is one, which carries out multiple, often wholly unrelated, functions. The RAD23 protein is a fascinating example of this, where the same polypeptide and the embedded domains function independently in both nucleotide excision repair (NER) and protein degradation via the ubiquitin-proteasome system (UPS). Hence, through direct binding to the central NER component XPC, RAD23 stabilizes XPC...

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Source

Identifiers

PMID: 36863450
DOI: 10.1016/j.bbagrm.2023.194925

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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