Article
Untangling population structure and genetic diversity of reticulocyte binding protein 2b (PvRBP2b) erythrocytic stage vaccine candidate in worldwide Plasmodium vivax isolates.
PloS one - 1 Jan 2022
Nourani Leila, Abouie Mehrizi Akram, Zakeri Sedigheh, Djadid Navid Dinparast
Abstract excerpt
BACKGROUNDS: Plasmodium vivax is the predominant Plasmodium species distributed extensively in the Americas and Asia-Pacific areas. Encoded protein by Plasmodium vivax Reticulocyte Binding Proteins (PvRBPs) family member are of critical prominence to parasite invasion and have been considered the significant targets in development of malaria vaccine for the blood stage. As high genetic polymorphism of parasites...
Topics
- Antigens, Protozoan
- Carrier Proteins
- Epitopes, B-Lymphocyte
- Genetic Variation
- Genetics, Population
- Iran
- Malaria Vaccines
- Nucleotides
- Plasmodium vivax
- Polymorphism, Single Nucleotide
- Protozoan Proteins
- Selection, Genetic
- Sequence Analysis, DNA