Article
Genetic variation among Plasmodium vivax isolates adapted to non-human primates and the implication for vaccine development.
The American journal of tropical medicine and hygiene - 1 Feb 2009
Ntumngia Francis B, McHenry Amy M, Barnwell John W, Cole-Tobian Jennifer, King Christopher L, Adams John H
Abstract excerpt
Plasmodium vivax Duffy binding protein (DBP) is vital for parasite development, thereby making this molecule a good vaccine candidate. Preclinical development of a P. vivax vaccine often involves use of primate models prior to testing efficacy in humans, but primate isolates are poorly characteri...
Topics
- Amino Acid Sequence
- Animals
- Antigens, Protozoan
- Disease Models, Animal
- Genetic Variation
- Humans
- Malaria Vaccines
- Malaria, Vivax
- Models, Molecular
- Molecular Sequence Data
- Phylogeny
- Plasmodium vivax
- Polymorphism, Genetic
- Primates
- Protozoan Proteins