Article
Genetic variation among Plasmodium vivax isolates adapted to non-human primates and the implication for vaccine development.
The American journal of tropical medicine and hygiene - 1 Feb 2009
Ntumngia Francis B, McHenry Amy M, Barnwell John W, Cole-Tobian Jennifer, King Christopher L, Adams John H
Abstract excerpt
Plasmodium vivax Duffy binding protein (DBP) is vital for parasite development, thereby making this molecule a good vaccine candidate. Preclinical development of a P. vivax vaccine often involves use of primate models prior to testing efficacy in humans, but primate isolates are poorly characterized. We analyzed the complete gene coding for the DBP in several P. vivax isolates that are used for experimental...
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