Article
Role of CYP4F2, CYP2C19, and CYP1A2 polymorphisms on acenocoumarol pharmacogenomic algorithm accuracy improvement in the Greek population: need for sub-phenotype analysis.
Drug metabolism and personalized therapy - 20 Dec 2017
Ragia Georgia, Karantza Ioanna-Maria, Kelli-Kota Eleni, Kolovou Vana, Kolovou Genovefa, Konstantinides Stavros, Maltezos Efstratios, Tavridou Anna, Tziakas Dimitrios, Maitland-van der Zee Anke H, Manolopoulos Vangelis G
Abstract excerpt
BACKGROUND: We have earlier developed a pharmacogenomic algorithm for acenocoumarol dose prediction in Greek patients that included CYP2C9/VKORC1 genetic information. This study aims at analyzing the potential effect of CYP4F2, CYP2C19, and CYP1A2 gene polymorphisms on acenocoumarol dose requirements and at further improving the Greek-specific pharmacogenomic algorithm. METHODS: A total of 205 Greek patients...
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