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Article

Essential requirement for nicastrin in marginal zone and B-1 B cell development.

Proceedings of the National Academy of Sciences of the United States of America - 3 Mar 2020

Choi Jin Huk, Han Jonghee, Theodoropoulos Panayotis C, Zhong Xue, Wang Jianhui, Medler Dawson, Ludwig Sara, Zhan Xiaoming, Li Xiaohong, Tang Miao, Gallagher Thomas, Yu Gang, Beutler Bruce

Abstract excerpt

γ-secretase is an intramembrane protease complex that catalyzes the proteolytic cleavage of amyloid precursor protein and Notch. Impaired γ-secretase function is associated with the development of Alzheimer's disease and familial acne inversa in humans. In a forward genetic screen of mice with N-ethyl-N-nitrosourea-induced mutations for defects in adaptive immunity, we identified animals within a single pedigree...

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Identifiers

PMID: 32071239
DOI: 10.1073/pnas.1916645117
PMCID: PMC7060662

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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