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Article

Deacetylation of MRTF-A by SIRT1 defies senescence induced down-regulation of collagen type I in fibroblast cells.

Biochimica et biophysica acta. Molecular basis of disease - 1 May 2020

Yang Yuyu, Li Zilong, Guo Junli, Xu Yong

Abstract excerpt

Aging provokes both morphological and functional changes in cells, which are accompanied by a fundamental shift in gene expression patterns. One of the characteristic alterations associated with senescence in fibroblast cells is the down-regulation of collagen type I genes. In the present study, we investigated the contribution of myocardin-related transcription factor A, or MRTF-A, in this process. In mouse...

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PMID: 32061777
DOI: 10.1016/j.bbadis.2020.165723

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