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Article

Sirtuin 7 is decreased in pulmonary fibrosis and regulates the fibrotic phenotype of lung fibroblasts.

American journal of physiology. Lung cellular and molecular physiology - 1 Jun 2017

Wyman Anne E, Noor Zahid, Fishelevich Rita, Lockatell Virginia, Shah Nirav G, Todd Nevins W, Atamas Sergei P

Abstract excerpt

Pulmonary fibrosis is a severe condition with no cure and limited therapeutic options. A better understanding of its pathophysiology is needed. Recent studies have suggested that pulmonary fibrosis may be driven by accelerated aging-related mechanisms. Sirtuins (SIRTs), particularly SIRT1, SIRT3, and SIRT6, are well-known mediators of aging; however, limited data exist on the contribution of sirtuins to lung...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28385812
DOI: 10.1152/ajplung.00473.2016
PMCID: PMC5495944

Genes

SIRT7
SIRT1
SIRT3
SIRT6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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