Article
Mutant p53 protein localized in the cytoplasm inhibits autophagy.
Cell cycle (Georgetown, Tex.) - 1 Oct 2008
Morselli Eugenia, Tasdemir Ezgi, Maiuri Maria Chiara, Galluzzi Lorenzo, Kepp Oliver, Criollo Alfredo, Vicencio José Miguel, Soussi Thierry, Kroemer Guido
Abstract excerpt
The knockout, knockdown or chemical inhibition of p53 stimulates autophagy. Moreover, autophagy-inducing stimuli such as nutrient depletion, rapamycin or lithium cause the depletion of cytoplasmic p53, which in turn is required for the induction of autophagy. Here, we show that retransfection of p53(-/-) HCT 116 colon carcinoma cells with wild type p53 decreases autophagy down to baseline levels. Surprisingly,...
Topics
- Autophagy
- Cytoplasm
- HCT116 Cells
- Humans
- Mutation
- Tumor Suppressor Protein p53