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HPV16 and HPV18 type-specific APOBEC3 and integration profiles in different diagnostic categories of cervical samples

25 Jun 2021

Abstract excerpt

Human papillomavirus (HPV) 16 and 18 are the most predominant types in cervical cancer. Only a small fraction of HPV infections progress to cancer, indicating that additional factors and genomic events contribute to the carcinogenesis, such as minor nucleotide variation caused by APOBEC3 and chromosomal integration. We analysed intra-host minor nucleotide variants (MNVs) and integration in HPV16 and HPV18...

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PMID: 34175494
DOI: 10.1016/j.tvr.2021.200221

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