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Article

The emergence of resistance to targeted cancer therapeutics.

Pharmacogenomics - 1 Sept 2002

Mellinghoff Ingo K, Sawyers Charles L

Abstract excerpt

Drug resistance has always been a concern in cancer treatment, often blamed on the genetic complexity and instability of tumor cells. While studies of cancer cell lines have implicated an array of potential mechanisms, it has been difficult to translate these insights into clinically meaningful improvements in cancer treatment. The successful deployment of molecularly targeted therapeutics in some cancers has led...

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PMID: 12223047
DOI: 10.1517/14622416.3.5.603

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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