Article
Single-cell transcriptional changes associated with drug tolerance and response to combination therapies in cancer.
Nature communications - 12 Mar 2021
Aissa Alexandre F, Islam Abul B M M K, Ariss Majd M, Go Cammille C, Rader Alexandra E, Conrardy Ryan D, Gajda Alexa M, Rubio-Perez Carlota, Valyi-Nagy Klara, Pasquinelli Mary, Feldman Lawrence E, Green Stefan J, Lopez-Bigas Nuria, Frolov Maxim V, Benevolenskaya Elizaveta V
Abstract excerpt
Tyrosine kinase inhibitors were found to be clinically effective for treatment of patients with certain subsets of cancers carrying somatic mutations in receptor tyrosine kinases. However, the duration of clinical response is often limited, and patients ultimately develop drug resistance. Here, we use single-cell RNA sequencing to demonstrate the existence of multiple cancer cell subpopulations within cell lines,...
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