A functional variant in TNXB promoter associates with the risk of esophageal squamous-cell carcinoma.

doi:10.1002/mc.23166

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A functional variant in TNXB promoter associates with the risk of esophageal squamous-cell carcinoma.

Molecular carcinogenesis - 1 Apr 2020

Yang Nan, Tian Jianbo, Wang Xiaoyang, Mei Shufang, Zou Danyi, Peng Xiating, Zhu Ying, Yang Yang, Gong Yajie, Ke Juntao, Zhong Rong, Chang Jiang, Miao Xiaoping

Abstract excerpt

Our previous study identified a tag single-nucleotide polymorphism (SNP) rs204900 in TNXB associated with risk of esophageal squamous-cell carcinoma (ESCC) in the Chinese population. However, the functional role of TNXB and causal variants had not been interrogated in that study. In the present study, we explored the effects of TNXB expression in the development of ESCC and searched for functional variants in...

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PMID: 32056283
DOI: 10.1002/mc.23166

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