Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

USP8 Mutations and Cell Cycle Regulation in Corticotroph Adenomas.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme - 1 Feb 2020

Martins Clarissa Silva, Camargo Renata Costa, Coeli-Lacchini Fernanda Borchers, Saggioro Fabiano Pinto, Moreira Ayrton Custodio, de Castro Margaret

Abstract excerpt

Corticotroph adenomas frequently harbor somatic USP8 mutations. These adenomas also commonly exhibit underexpression of P27, a cell cycle regulator. The present study aimed to determine the influence of USP8 mutations on clinical features of Cushing's disease and to elucidate the relationship between USP8 mutations and P27 underexpression in these tumors. Retrospective study with 32 patients with Cushing's...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adrenocorticotropic Hormone
Share to Brazil

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Cycle

Share to Cell Cycle Proteins

Share to Endopeptidases

Share to Endosomal Sorting Complexes Required for Transport

Share to Ubiquitin Thiolesterase

Source

Identifiers

PMID: 32053843
DOI: 10.1055/a-1089-7806

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

USP8 Mutations and Cell Cycle Regulation in Corticotroph Adenomas.PMID 32053843Read ↗

Clinical Spectrum of USP8 Pathogenic Variants in Cushing's DiseaseSemantic proximity Read ↗

Relevance of mutations in protein deubiquitinases genes and TP53 in corticotroph pituitary tumors.Semantic proximity Read ↗

USP8 mutations in corticotroph adenomas determine a distinct gene expression profile irrespective of functional tumour statusSemantic proximity Read ↗

Mutations in the deubiquitinase gene USP8 cause Cushing's disease.Semantic proximity Read ↗

Impact of USP8 Gene Mutations on Protein Deregulation in Cushing DiseaseSemantic proximity Read ↗

PATHOGENESIS OF CUSHING DISEASE: AN UPDATE ON THE GENETICS OF CORTICOTROPINOMAS.Semantic proximity Read ↗

Somatic USP8 mutations are frequent events in corticotroph tumor progression causing Nelson's tumor.Semantic proximity Read ↗

Identification of recurrent USP48 and BRAF mutations in Cushing's disease.Semantic proximity Read ↗

The New Genetic Landscape of Cushing’s Disease: Deubiquitinases in the SpotlightSemantic proximity Read ↗

Genetic Profiling of a Cohort of Italian Patients with ACTH-Secreting Pituitary Tumors and Characterization of a Novel USP8 Gene VariantSemantic proximity Read ↗

Decoding the genetic basis of Cushing's disease: USP8 in the spotlight.Semantic proximity Read ↗

Recurrent gain-of-function USP8 mutations in Cushing's diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.