Article
Traditional serrated adenoma has two distinct genetic pathways for molecular tumorigenesis with potential neoplastic progression.
Journal of gastroenterology - 1 Sept 2020
Tanaka Yoshihito, Eizuka Makoto, Uesugi Noriyuki, Kawasaki Keisuke, Yamano Hiroo, Suzuki Hiromu, Matsumoto Takayuki, Sugai Tamotsu
Abstract excerpt
BACKGROUND: Recent studies have shown that traditional serrated adenoma (TSA) can be classified into BRAF and KRAS subtypes. Here, we examined the clinicopathological and molecular findings of 73 TSAs. MATERIALS AND METHODS: TSAs were subclassified into BRAF type (46 cases, type A) and KRAS type (27 cases, type B) and divided into polyp head (TSA component) and base (precursor component [PC]) to identify...
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