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Stroma remodeling and reduced cell division define durable response to PD-1 blockade in melanoma

12 Feb 2020

Abstract excerpt

Although immune checkpoint inhibitors (ICIs) have achieved unprecedented results in melanoma, the biological features of the durable responses initiated by these drugs remain unknown. Here we show the genetic and phenotypic changes induced by treatment with programmed cell death-1 (PD-1) blockade in a genetically engineered mouse model of melanoma driven by oncogenic BRAF. In this controlled system anti-PD-1...

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PMID: 32051401
DOI: 10.1038/s41467-020-14632-2

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