Article
Transcriptional downregulation of MHC class I and melanoma de- differentiation in resistance to PD-1 inhibition
20 Apr 2020
Abstract excerpt
Abstract Transcriptomic signatures designed to predict melanoma patient responses to PD-1 blockade have been reported but rarely validated. We now show that intra-patient heterogeneity of tumor responses to PD-1 inhibition limit the predictive performance of these signatures. We reasoned that resistance mechanisms will reflect the tumor microenvironment, and thus we examined PD-1 inhibitor resistance relative to...
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