Variants in LRRC34 reveal distinct mechanisms for predisposition to papillary thyroid carcinoma.

doi:10.1136/jmedgenet-2019-106554

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Article

Variants in LRRC34 reveal distinct mechanisms for predisposition to papillary thyroid carcinoma.

Journal of medical genetics - 1 Aug 2020

Comiskey Daniel Forrest, He Huiling, Liyanarachchi Sandya, Sheikh Mehek S, Genutis Luke K, Hendrickson Isabella V, Yu Lianbo, Brock Pamela L, de la Chapelle Albert

Abstract excerpt

BACKGROUND: Papillary thyroid carcinoma (PTC) demonstrates high heritability and a low somatic mutation burden relative to other cancers. Therefore, the genetic risk predisposing to PTC is likely due to a combination of low penetrance variants. A recent genome-wide association study revealed the association of PTC with a missense variant, rs6793295, at 3q26 in a gene called Leucine Repeat Rich Containing 34...

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PMID: 32051256
DOI: 10.1136/jmedgenet-2019-106554

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