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Article

The polymorphism rs944289 predisposes to papillary thyroid carcinoma through a large intergenic noncoding RNA gene of tumor suppressor type.

Proceedings of the National Academy of Sciences of the United States of America - 29 May 2012

Jendrzejewski Jaroslaw, He Huiling, Radomska Hanna S, Li Wei, Tomsic Jerneja, Liyanarachchi Sandya, Davuluri Ramana V, Nagy Rebecca, de la Chapelle Albert

Abstract excerpt

A genome-wide association study of papillary thyroid carcinoma (PTC) pinpointed two independent SNPs (rs944289 and rs965513) located in regions containing no annotated genes (14q13.3 and 9q22.33, respectively). Here, we describe a unique, long, intergenic, noncoding RNA gene (lincRNA) named Papillary Thyroid Carcinoma Susceptibility Candidate 3 (PTCSC3) located 3.2 kb downstream of rs944289 at 14q.13.3 and the...

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Share to Blotting, Northern
Share to Carcinoma, Papillary
Share to CCAAT-Enhancer-Binding Protein-beta
Share to Chlorocebus aethiops
Share to Chromosomes, Human, Pair 14
Share to Genes, Tumor Suppressor
Share to RNA, Untranslated
Share to Thyroid Neoplasms

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Identifiers

PMID: 22586128
DOI: 10.1073/pnas.1205654109
PMCID: PMC3365219

Genes

EBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The polymorphism rs944289 predisposes to papillary thyroid carcinoma through a large intergenic noncoding RNA gene of tumor suppressor type.PMID 22586128Read ↗

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