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Association between molecular lesions and specific B-cell receptor subsets in chronic lymphocytic leukemia

2 May 2013

Abstract excerpt

Genetic lesions and B-cell receptor (BCR) signaling are both oncogenic drivers in chronic lymphocytic leukemia (CLL). However, scant data are available on preferential associations between specific genetic alterations and stereotyped BCR subsets. By analyzing 1419 cases, 2 CLL subsets (2 and 8) harboring stereotyped BCR are enriched in specific molecular alterations influencing disease course. SF3B1 mutations are...

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PMID: 23637131
DOI: 10.1182/blood-2013-02-486209

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