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Biosynthesis of the terpene phenalinolactone in Streptomyces sp. Tü6071: analysis of the gene cluster and generation of derivatives.

Chemistry & biology - 1 Apr 2006

Dürr Clemens, Schnell Hans-Jörg, Luzhetskyy Andriy, Murillo Renato, Weber Monika, Welzel Katrin, Vente Andreas, Bechthold Andreas

Abstract excerpt

Phenalinolactones are terpene glycosides with antibacterial activity. A striking structural feature is a highly oxidized gamma-butyrolactone of elusive biosynthetic origin. To investigate the genetic basis of the phenalinolactones biosynthesis, we cloned and sequenced the corresponding gene cluster from the producer strain Streptomyces sp. Tü6071. Spanning a 42 kbp region, 35 candidate genes could be assigned to...

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PMID: 16632249
DOI: 10.1016/j.chembiol.2006.01.011

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