Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

H3K27me3 and EZH2 expression in melanoma: relevance for melanoma progression and response to immune checkpoint blockade.

Clinical epigenetics - 10 Feb 2020

Hoffmann Friederike, Niebel Dennis, Aymans Pia, Ferring-Schmitt Sandra, Dietrich Dimo, Landsberg Jennifer

Abstract excerpt

BACKGROUND: Upregulation of the histone methyltransferase enzyme EZH2 and its histone modification H3K27me3 has been linked to melanoma progression, metastasis, and resistance to immune checkpoint blockade (ICB). In clinical trials, EZH2 inhibitors are currently tested to overcome resistance to ICB. The aim of this study is to evaluate expression patterns and the predictive value of H3K27me3 and EZH2 in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Clinical Trials as Topic
Share to Enhancer of Zeste Homolog 2 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histones

Share to Immune Checkpoint Inhibitors

Share to Melanoma

Share to Neoplasm Invasiveness

Share to Neoplasm Metastasis

Share to Predictive Value of Tests

Source

Open in PubMed Open full text

Identifiers

PMID: 32041674
DOI: 10.1186/s13148-020-0818-7
PMCID: PMC7011516

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

H3K27me3 and EZH2 expression in melanoma: relevance for melanoma progression and response to immune checkpoint blockade.PMID 32041674Read ↗

Epigenetic Modifications in Cutaneous Malignant MelanomaSemantic proximity Read ↗

B7-H3 is associated with the armored-cold phenotype and predicts poor immune checkpoint blockade response in melanoma.Semantic proximity Read ↗

The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressors.Semantic proximity Read ↗

EZH2 Cooperates with DNA Methylation to Downregulate Key Tumor Suppressors and IFN Gene Signatures in Melanoma.Semantic proximity Read ↗

EZH2 in Acral Lentiginous Melanoma: Molecular, Epigenetic, and Therapeutic Perspectives.Semantic proximity Read ↗

Ezh2Y641F mutations co-operate with Stat3 to regulate MHC class I antigen processing and alter the tumor immune response in melanoma.Semantic proximity Read ↗

Stat3 co-operates with mutant <i>Ezh2</i> <sup>Y641F</sup> to regulate gene expression and limit the anti-tumor immune response in melanomaSemantic proximity Read ↗

Targeting DNA Methylation and EZH2 Activity to Overcome Melanoma Resistance to ImmunotherapySemantic proximity Read ↗

EZH2-mediated H3K27me3 is a predictive biomarker and therapeutic target in uveal melanomaSemantic proximity Read ↗

Somatic Copy Number Amplification and Hyperactivating Somatic Mutations of EZH2 Correlate With DNA Methylation and Drive Epigenetic Silencing of Genes Involved in Tumor Suppression and Immune Responses in Melanoma.Semantic proximity Read ↗

Mi-2β promotes immune evasion in melanoma by activating EZH2 methylationSemantic proximity Read ↗

The Histone Methyltransferase Ezh2 Controls Mechanisms of Adaptive Resistance to Tumor ImmunotherapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.