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Article

Epigenetic Modifications in Cutaneous Malignant Melanoma

7 May 2013

Abstract excerpt

Cancer stem cells and the misregulation of epigenetic modifications have been identified to possess a determinative role in carcinogenesis. The purpose of this study was to investigate the expression profile of EZH2 and H3K4me2 and H3K27me3, which constitute stem cell-like "bivalent" domains, in cutaneous malignant melanoma. A comparative analysis of their immunohistochemical expression between the invasion front...

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PMID: 25614949
DOI: 10.1097/dad.0b013e31828a2d54

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