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Targeting DNA Methylation and EZH2 Activity to Overcome Melanoma Resistance to Immunotherapy

7 Mar 2019

Abstract excerpt

Methylation of DNA at CpG sites is the most common and stable of epigenetic changes in cancer. Hypermethylation acts to limit immune checkpoint blockade immunotherapy by inhibiting endogenous interferon responses needed for recognition of cancer cells. By contrast, global hypomethylation results in the expression of programmed death ligand 1 (PD-L1) and inhibitory cytokines, accompanied by epithelial-mesenchymal...

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PMID: 30853334
DOI: 10.1016/j.it.2019.02.004

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