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Article

Intratumoral Heterogeneity in a Trp53 -Null Mouse Model of Human Breast Cancer

3 Mar 2015

Abstract excerpt

UNLABELLED: Intratumoral heterogeneity correlates with clinical outcome and reflects the cellular complexity and dynamics within a tumor. Such heterogeneity is thought to contribute to radio- and chemoresistance because many treatments may target only certain tumor cell subpopulations. A better understanding of the functional interactions between various subpopulations of cells, therefore, may help in the...

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PMID: 25735774
DOI: 10.1158/2159-8290.cd-14-1101

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