Article
APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy.
Nature communications - 7 Feb 2020
Driscoll Christopher B, Schuelke Matthew R, Kottke Timothy, Thompson Jill M, Wongthida Phonphimon, Tonne Jason M, Huff Amanda L, Miller Amber, Shim Kevin G, Molan Amy, Wetmore Cynthia, Selby Peter, Samson Adel, Harrington Kevin, Pandha Hardev, Melcher Alan, Pulido Jose S, Harris Reuben, Evgin Laura, Vile Richard G
Abstract excerpt
APOBEC3B, an anti-viral cytidine deaminase which induces DNA mutations, has been implicated as a mediator of cancer evolution and therapeutic resistance. Mutational plasticity also drives generation of neoepitopes, which prime anti-tumor T cells. Here, we show that overexpression of APOBEC3B in tumors increases resistance to chemotherapy, but simultaneously heightens sensitivity to immune checkpoint blockade in a...
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