Article
Cancer immunotherapy. A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells.
Science (New York, N.Y.) - 15 May 2015
Carreno Beatriz M, Magrini Vincent, Becker-Hapak Michelle, Kaabinejadian Saghar, Hundal Jasreet, Petti Allegra A, Ly Amy, Lie Wen-Rong, Hildebrand William H, Mardis Elaine R, Linette Gerald P
Abstract excerpt
T cell immunity directed against tumor-encoded amino acid substitutions occurs in some melanoma patients. This implicates missense mutations as a source of patient-specific neoantigens. However, a systematic evaluation of these putative neoantigens as targets of antitumor immunity is lacking. Moreover, it remains unknown whether vaccination can augment such responses. We found that a dendritic cell vaccine led to...
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