Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The double-edged sword of cancer mutations: exploiting neoepitopes for the fight against cancer.

Mutagenesis - 13 Feb 2020

Alvarado-Cruz Isabel, Meas Rithy, Paluri Sesha Lakshmi Arathi, Carufe Kelly Estelle Wheeler, Khan Mohammed, Sweasy Joann Balazs

Abstract excerpt

Defects in DNA repair have been linked to the accumulation of somatic mutations in tumours. These mutations can promote oncogenesis; however, recent developments have indicated that they may also lead to a targeted immune response against the tumour. This response is initiated by the development of new antigenic epitopes (neoepitopes) arising from mutations in protein-coding genes that are processed and then...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Neoplasm
Share to DNA Damage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Repair

Share to Immune Checkpoint Inhibitors

Share to Immunotherapy

Share to Mutation

Share to Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 31880305
DOI: 10.1093/mutage/gez049
PMCID: PMC7016206

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The double-edged sword of cancer mutations: exploiting neoepitopes for the fight against cancer.PMID 31880305Read ↗

Progress in Neoantigen Targeted Cancer ImmunotherapiesSemantic proximity Read ↗

Targeting Neoepitopes to Treat Solid Malignancies: ImmunosurgerySemantic proximity Read ↗

Cancer immunotherapy: broadening the scope of targetable tumours.Semantic proximity Read ↗

New emerging targets in cancer immunotherapy: the role of neoantigensSemantic proximity Read ↗

Immunopharmacogenomics towards personalized cancer immunotherapy targeting neoantigens.Semantic proximity Read ↗

Neoantigens Generated by Individual Mutations and Their Role in Cancer Immunity and ImmunotherapySemantic proximity Read ↗

Boosting Antitumor Immunity with an Expanded Neoepitope Landscape.Semantic proximity Read ↗

Neoepitopes of Cancers: Looking Back, Looking Ahead.Semantic proximity Read ↗

Identification and Targeting of Mutant Peptide Neoantigens in Cancer ImmunotherapySemantic proximity Read ↗

Relevance of mutation-derived neoantigens and non-classical antigens for anticancer therapies.Semantic proximity Read ↗

Mutanome directed cancer immunotherapy.Semantic proximity Read ↗

Neoantigen-based personalized cancer vaccines: the emergence of precision cancer immunotherapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.