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Article

p73 – NAV3 axis plays a critical role in suppression of colon cancer metastasis

6 Feb 2020

Abstract excerpt

p73 is a member of the p53 tumor suppressor family, which transactivates p53-responsive genes and mediates DNA damage response. Recent evidences suggest that p73 exerts its tumor suppressor functions by suppressing metastasis, but the exact mechanism remains unknown. Here, we identify Navigator-3 (NAV3), a microtubule-binding protein, as a novel transcriptional target of p73, which gets upregulated by DNA damage...

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PMID: 32029709
DOI: 10.1038/s41389-020-0193-4

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