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Article

Prognostic Impact of ΔTAp73 Isoform Levels and Their Target Genes in Colon Cancer Patients

2 Aug 2011

Abstract excerpt

PURPOSE: Cumulative data support the role of ΔTAp73 variants in tumorigenic processes such as drug resistance. We evaluate the impact of TP73 isoforms and their putative target genes ABCB1, HMGB1, and CASP1 on the survival of colon cancer patients and the correlation between their expressions. EXPERIMENTAL DESIGN: We determined in 77 colon cancer patients the expression of ΔEx2p73, ΔEx2/3p73, ΔNp73, TAp73, ABCB1,...

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PMID: 21807636
DOI: 10.1158/1078-0432.ccr-10-2388

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