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Article

A microRNA-dependent program controls p53-independent survival and chemosensitivity in human and murine squamous cell carcinoma

12 Jan 2011

Abstract excerpt

The p53 tumor suppressor, a central mediator of chemosensitivity in normal cells, is functionally inactivated in many human cancers. Therefore, a central challenge in human cancer therapy is the identification of pathways that control tumor cell survival and chemosensitivity in the absence of functional p53. The p53-related transcription factors p63 and p73 exhibit distinct functions—p73 mediates chemosensitivity...

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PMID: 21293058
DOI: 10.1172/jci43897

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