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Article

The loss-of-function mutations and down-regulated expression of ASB3 gene promote the growth and metastasis of colorectal cancer cells.

Chinese journal of cancer - 14 Jan 2017

Du Wu-Ying, Lu Zhen-Hai, Ye Wen, Fu Xiang, Zhou Yi, Kuang Chun-Mei, Wu Jiang-Xue, Pan Zhi-Zhong, Chen Shuai, Liu Ran-Yi, Huang Wen-Lin

Abstract excerpt

BACKGROUND: Ankyrin repeat and SOCS box protein 3 (ASB3) is a member of ASB family and contains ankyrin repeat sequence and SOCS box domain. Previous studies indicated that it mediates the ubiquitination and degradation of tumor necrosis factor receptor 2 and is likely involved in inflammatory responses. However, its effects on oncogenesis are unclear. This study aimed to investigate the effects of ASB3 on the...

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Identifiers

PMID: 28088228
DOI: 10.1186/s40880-017-0180-0
PMCID: PMC5237493

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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