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Article

Navigator‐3, a modulator of cell migration, may act as a suppressor of breast cancer progression

12 Feb 2015

Abstract excerpt

Dissemination of primary tumor cells depends on migratory and invasive attributes. Here, we identify Navigator-3 (NAV3), a gene frequently mutated or deleted in human tumors, as a regulator of epithelial migration and invasion. Following induction by growth factors, NAV3 localizes to the plus ends of microtubules and enhances their polarized growth. Accordingly, NAV3 depletion trimmed microtubule growth,...

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PMID: 25678558
DOI: 10.15252/emmm.201404134

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